Ultrasound and Fluorescent Evaluation of Biomarker Activated Nanoparticles for Chemotherapeutic Breast Cancer Delivery By

Chemotherapy is an area in need of medical advancement due to its wide use for cancer treatment and unavoidable side effects which affect overall patient outcome. Targeted nanoparticle drug delivery has shown the potential to address challenges presented by modern chemotherapeutic treatments. This field of study focuses nano-scaled vehicles composed of various biocompatible polymers to diagnose, monitor, and treat diseases at a molecular level. Because of their novel designs, nanoparticles have the potential to improve drug solubility, prolong systemic circulation, help localize delivery, and increase drug efficacy. This study reports a novel biomarker activated nanovehicle for the delivery of doxorubicin to treat breast malignancies. Cell culture models are used to investigate biomarker specificity and efficacy while animal models are studied for release dynamics. Results show localized drug release with the capability to detect these nanoparticles through ultrasonic and fluorescent imaging techniques.